Interestingly, we observed a negative correlation between the basal level of adiponectin and the HOMA-IR index (r = −0.306, P = 0.02); additionally, we found that the responses of these two variables, calculated as fold change from basal, were positively associated (r = −0.328, P = 0.01), indicating that the increased level of adiponectin, due to TRE protocol, corresponded to a lower insulin resistance. The gene discussed is ADIPOQ; the disease is Insulin resistance.