In addition to human ELR+ CXC chemokines, SpyCEP cleaves the murine CXCL1 and CXCL2 homologues MIP-2 and KC, which signal via mCXCR2 and play a significant role in recruiting neutrophils to the sites of infection in mice [40, 55, 56, 57]. The gene discussed is CXCL1; the disease is infection.