CXCL8 and infection: In addition to CXCL8, SpyCEP cleaves all neutrophil-specific chemokines that possess an ELR motif, namely, CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, and CXCL7, thereby inhibiting the recruitment of neutrophils to sites of infection and inflammation [44, 45].