Although depletion of ACE2 by SARS-CoV-2 may directly disrupt or inhibit the psychoneuroendocrine pathways related to stress, anxiety, and depression, it is additionally important to note the indirect effects on these pathways due to viral-induced neuroinflammation, particularly in light of the relatively minimal amount of virus within the CNS itself. The gene discussed is ACE2; the disease is depressive disorder.