ACE and heart failure: They had more often been diagnosed with comorbidities (ischemic heart disease 23.3% versus 1.6%, heart failure 9.45% versus 2.13%, hypertension 74.3% versus 24.7%, type 2 diabetes 32.6% versus 4.75%) and were more frequently on anticoagulant and antihypertensive treatments (ACE inhibitors 2.7% versus 1.1%; angiotensin receptor blockers 3.6% versus 1.6% and anticoagulants 5.0% versus 2.1%) compared to nonusers.