We also assessed drug-induced RyR leak (mimicking CPVT, [18]) and enhanced INaL (mimicking long QT3, [24]) in control rabbit cardiomyocytes, and in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) carrying arrhythmogenic SCN5A N406K mutation [60]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.