In 2 other studies, enrichment of rare CFH variants was observed in CCP domains 1 to 4 and 19 to 20 in individuals with advanced AMD,30 and in CCP 3, 5, and 7 in individuals with AMD.31 The first 7 CCP domains of FH are identical to FHL-1. Here, FH is linked to age-related macular degeneration.