The minor allele frequencies of main risk alleles CFH rs570618 and ARMS2/HTRA1 rs3750846 were lower in individuals with EODM compared with individuals with AMD (74 of 148 [50.0%] vs 97 of 174 [55.7%]; χ2P = .30 and 34 of 148 [23.0%] vs 67 of 174 [38.5%]; χ2P = .003, respectively). Here, CFH is linked to age-related macular degeneration.