In this study, we aimed to describe phenotypic characteristics, determine the contribution of 52 AMD-associated variants using genetic risk score (GRS), and perform a comprehensive analysis of the coding and splice-site regions of CFH, CFI, C3, C9, CFB, ABCA4, PRPH2, TIMP3, and CTNNA1 in a cohort of 89 patients with EODM and compare these characteristics with characteristics of patients with AMD. Here, C3 is linked to age-related macular degeneration.