Caution is warranted, considering the phenotypic overlap between EODM and macular dystrophies, such as Mallatia Leventinese, SFD, and CACD.16,24 A previous family-based study by Klevering et al35 showed a range of phenotypes in patients with CACD carrying the PRPH2 Arg142Trp mutation. Here, PRPH2 is linked to Macular dystrophy.