MEN1 and pancreatic neuroendocrine tumor: MEN1, DAXX and ATRX are the most frequently mutated genes in pancreatic G1-G2 NET (Ki-67 < 20%) (Jiao et al. 2011), and similar alterations are reported in pancreatic NET G3 (Yachida et al. 2012, Tang et al. 2016a, Konukiewitz et al. 2018).