Regarding proliferation phenotype, despite the small number of NEC with Ki-67 21–55% (n = 13) compared to NEC with Ki-67 > 55% (n = 130), CNA in MYC was the only significant difference (enrichment) seen in NEC with Ki-67 21–55% (P = 0.018; Supplementary Fig. 2). This evidence concerns the gene MYC and neuroendocrine carcinoma.