TP53 mutations in GEP-NEC are found in 57–59% (Vijayvergia et al. 2016, Busico et al. 2020), in colorectal NEC in 50–84% (Shamir et al. 2019, Capdevila et al. 2020) and in 8/12 pancreatic NEC (Konukiewitz et al. 2018). This evidence concerns the gene TP53 and pancreatic endocrine carcinoma.