The colocalization rate of LC3‐II and CD68 in infected diabetic rats was 84.51 ± 4.22%, significantly higher than that in noninfected diabetic infected rats (44.32 ± 2.67%; p < .05), and meant that infection can trigger autophagy of dermis macrophages in diabetic rats (Figure 5C). The gene discussed is CD68; the disease is infection.