We also found that many immune cells are co‐regulated by the m6A regulator, such as eosinophils, which are closely related to severe asthma, the abundance of eosinophils is positively correlated with YTHDF3 and negatively correlated with EIF3B, which proves that the expression of YTHDF3 and EIF3B has a close influence on eosinophils in the pathogenesis of severe asthma. The gene discussed is EIF3B; the disease is asthma.