GNAS and pancreatic intraductal papillary-mucinous neoplasm: Single cases of published pancreatic MiNEN revealed a close relationship to PDAC [15], as it was also found in colorectal MiNEN [52, 58], and interestingly also to its precursors, as two cases of pancreatic intraductal papillary mucinous neoplasms (IPMN) associated with NEN were reported, in which the NEN component showed GNAS mutations, typical for IPMN.