Considering its ability to transport nucleoside-derived drugs, its role beyond mere substrate-translocation functions and its decreased expression in some tumors, we analyzed hCNT1 expression in two different digestive cancers currently treated with fluoropyrimidines: colorectal carcinoma (CRC) and pancreatic ductal adenocarcinoma (PDAC). Here, SLC28A1 is linked to colorectal carcinoma.