The infiltration of the immune cells into the TME can be a prognostic factor of NSCLC.20, 21, 22, 23 Reports have found that a higher number of CD4+ T-cells and CD8+ T-cells in the stroma, but not in the areas of cancer cells, is associated with a better prognosis after surgery for NSCLC.20 This evidence concerns the gene CD8A and cancer.