Interestingly, a recent study on H3K27M-mutant DMGs in adults have found divergent clinical and genetic profiles compared to pediatric tumors, such as a higher predilection of thalamic and spinal cord involvement, K27M mutation exclusively in the H3-3A gene, lower incidence of PDGFRA amplification, and absence of ACVR1 mutation in the adult patients.3 In this study, there was better overall survival in adults compared to both pediatric H3K27M-mutant DMGs and adult IDH-wildtype glioblastoma, questioning the aggressive behavioral role ascribed to H3K27M mutation in adult patients. This evidence concerns the gene ACVR1 and glioblastoma.