C1GALT1 and hepatocellular carcinoma: For instance, overexpression of core 1 β1,3-galactosyltransferase (C1GALT1) modifying the core 1 O-glycans on β1 integrin increased cell adhesion to ECM coinciding with an advanced tumor stage and poor survival in hepatocellular carcinoma (Liu et al., 2014).