B3GNT6 and prostate carcinoma: By contrast, the β3-N-acetylglucosaminyltransferase-6 (B3GNT6) modifies core 3 O-glycan leading to decreased levels of the α2β1 integrin, decreased activation of focal adhesion kinase and lamellipodia formation which, in turn, suppresses tumor formation and metastasis of prostate carcinoma (Lee et al., 2009).