In the AMD-related dataset (GSE50195), a study by Zhao et al. indicated that between AMD and healthy retinal tissue, TNC, GRP, TRAF6, ADAMTS5, GPX3, FAP, DHCR7, and FDFT1 genes acted as upstream factors for pathogenesis in AMD [59]. The gene discussed is GPX3; the disease is age-related macular degeneration.