Such low prevalence of LVSD, asymptomatic of HF cohort, is unexpected given that 86.3% of our patients were overweight/pre-obese/obese, 83.1% had been diagnosed with T2DM for more than a decade (60.1% insulin requiring), 77.1% had hypertension, and 91.0% dyslipidemia. The gene discussed is INS; the disease is type 2 diabetes mellitus.