For example, Myo-inositol oxygenase (MIOX) expression was shown to be increased in kidneys of db/db mice and streptozotocin (STZ)-treated diabetic mice contributing to progression of DKD, and linked to enhanced DRP1 and FIS1 expression with decreased MFN2 expression (98, 108). The gene discussed is FIS1; the disease is diabetic kidney disease.