Although several studies have reported that some serum biomarkers, including ferritin, KL-6, and IL-18, were related to RP-ILD and might be used as potential biomarkers for predicting disease severity and prognosis (10, 33); the researchers of the study were unable to include these markers in the model due to the lack of these data in the retrospective study, whether those markers could be used as a reliable alternative biomarker needs further validation. The gene discussed is IL18; the disease is interstitial lung disease.