Multivariable logistic regression analysis indicated that fever, periungual erythema, anti-MDA5 antibody, anti-Ro-52 antibody, and elevated CRP were independent risk factors for RP-ILD in DM/CADM patients [fever: odds ratio (OR) = 3.407, 95% CI = 1.462-7.942, p = 0.005; periungual erythema: OR = 5.911, 95% CI = 1.886–18.531, p = 0.002; anti-MDA5 antibody: OR = 8.721, 95% CI = 3.147–24.166, p = 0.000; anti-Ro-52 antibody: OR = 6.244, 95% CI = 2.565–15.200, p = 0.000; elevated CRP: OR = 4.039, 95% CI = 1.679–9.716, p = 0.002; Table 1]. This evidence concerns the gene IFIH1 and interstitial lung disease.