Ren et al. (2020) suggested that the loss of function of FUNDC1 inhibits mitophagy and causes deterioration in cardiac function in DCM. In diet-induced obesity, FUNDC1 was found to regulate mitochondrial quality and affect metabolism via MAPK signaling (Wu H. et al., 2019). However, it has also been shown that a decrease in FUNDC1 expression relieves calcium overload in mitochondria, thereby ameliorating diabetic heart disease (Wu S. et al., 2019). Here, FUNDC1 is linked to obesity due to melanocortin 4 receptor deficiency.