EIF4EBP1 and cancer: Interestingly, IL-6 was also found to induce the production of Survivin, an inhibitor of apoptosis, in cancer cells (Duluc et al., 2015); the authors also identified that mTOR/4E-BP1 signaling is activated in cancer cells as a response to CAF-secreted factors and plays a role in imparting chemoresistance.