CAFs also seem to protect pancreatic cancer cells from gemcitabine treatment via exosomal Snail and miR-146a that enhance the proliferative capacity of the cancer cells and induces EMT, which is linked with resistance and metastasis (Richards et al., 2017); interestingly, exosome secretion was upregulated as a result of gemcitabine treatment, which highlights the importance of CAFs in acquired pancreatic cancer resistance. The gene discussed is SNAI1; the disease is familial pancreatic carcinoma.