The group showed that pancreatic cancer cell-derived exosomes containing Lin28B (Exo-Pan and Exo-Mia) promoted the recruitment of PSCs by activating the Lin28B/let-7/HMGA2/PDGFB signaling pathway, which highlights the importance of exosomal signaling in cancer. The gene discussed is LIN28B; the disease is familial pancreatic carcinoma.