The overlapping targets (AKR1B1, TLR4, ESR1, PRKCQ, PIK3CD, CTSK, MMP2, ADRB2, PDE1C, ITGB3, PDE10A, PTGFR, AR and PTGER3) were considered as the key genes for the CKI treatment of GC. The gene discussed is PDE1C; the disease is gastric cancer.