The overlapping targets (AKR1B1, TLR4, ESR1, PRKCQ, PIK3CD, CTSK, MMP2, ADRB2, PDE1C, ITGB3, PDE10A, PTGFR, AR and PTGER3) were considered as the key genes for the CKI treatment of GC. The gene discussed is ESR1; the disease is gastric cancer.