SPP1 and neoplasm: The IHC analysis of 12 tumor samples (six cases of lymph node metastasis and six cases of non-metastasis) and nine paracancerous samples showed that SPP1 had lower H-scores in tumor tissues (Figures 8C,D, p < 0.05), and the H-score of the lymph node metastatic group was significantly higher than that of the non-metastatic group (Figures 8C,E, p < 0.05).