In addition, using the survival data for the GSE68465 cohort, we demonstrated that early lymph node metastasis (p < 0.001, Figure 6E), higher M0 infiltration (p = 0.035, Figure 6F), and higher SPP1 expression (p = 0.023, Figure 6G) were significantly associated with the poor prognosis among patients with Stage-T1 LUAD. Here, SPP1 is linked to metastatic malignant neoplasm in the lymph nodes.