Nevertheless, several astrocyte/glia risk factor genes, such as APOE, particularly the E4 isoform (Pihlstrøm et al., 2018) or Clusterin (CLU) and FERM Domain Containing Kindlin 2 (FERMT2) (Verheijen and Sleegers, 2018), have been identified for AD. Here, CLU is linked to Alzheimer disease.