Jia-Hau Yen et al demonstrated that TIIA-mediated autophagy occurred in a SESN2-dependent but not Beclin-1-dependent manner in human osteosarcoma 143B cells, suggesting that SESN2 is a potential molecular target for cancer therapy (Yen et al., 2018; Jeong et al., 2019). Here, SESN2 is linked to osteosarcoma.