TMPRSS2 and posterior cortical atrophy: These organoids capsulate the molecular diversity and clinical heterogeneity of PCa subtypes, including TMPRSS2-ERG fusion, ETS translocation, SPOP mutation, SPINK1 overexpression, FOXA1 and PIK3R1 mutation, CHD1 deletion, PTEN deletion, and AR expression, and retain the genomic characteristics of primary tumors.