Additionally, androgen signaling- therapies may provide a protective effect in infected cancer patients; these therapies are routinely used in the treatment of advanced prostate cancer, could restrict SARS-CoV-2 infection by down-regulating the expression of TMPRSS2 and stimulates an anti-SARS-CoV-2 immune response (15). The gene discussed is TMPRSS2; the disease is prostate carcinoma.