The analyzed results demonstrated that RFWD2 is remarkably upregulated in the tissues of numerous kinds of tumors, including bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma (CESC), cholangiocarcinoma (CHOL), esophageal carcinoma (ESCA), glioblastoma multiforme (GBM), stomach adenocarcinoma (STAD), etc., compared with control tissues (Figure 7A). This evidence concerns the gene COP1 and bladder transitional cell carcinoma.