VEGFA and neoplasm: Multiple anti-VEGF therapy studies in patients with progressive NF2-VS have shown that bevacizumab can not only ameliorate hearing loss and reduce tumor size (68), but also normalize the tumor vasculature and reduce vasogenic edema, which improved the delivery of oxygenation, a potent radiosensitizer, and therefore reduced radiation dose and minimized radiation-related neurotoxicity (69).