NF2 and schwannoma: Although no studies have directly confirmed the correlation between VS tumorigenesis and CRL4DCAF1 activity, targeted inhibition of the upstream activator of CRL4DCAF1, NEDD8-activating enzyme (NAE), can induce inhibitory YAP phosphorylation and reduce cell proliferation in mouse neurofibromin 2-mutant schwannoma cells and human neurofibromin 2-mutant mesothelioma cell line (96), indicating a growth-promoting role of CRL4DCAF1 in neurofibromin 2-inactivated tumors.