And KEGG analysis showed the key pathways correlated with the alcohol-related HCC samples: cell cycle, oocyte meiosis, mineral absorption, progesterone-mediated oocyte maturation, p53 signaling pathway, fanconi anemia pathway and Homologous recombination(P < 0.05)(Figure 2D). The gene discussed is TP53; the disease is hepatocellular carcinoma.