The following targets were selected based on miRNA pathway maps and networks from MetaCoreTM analysis, together with chip array data (BC patients) from our previous work (data not shown) (20): MYB, EZH2, MITF, SNX1, and SIP1. Although the latter is recognized as relevant for EMT, and for this matter is relevant in BC, the ultimate question here is whether this gene may be regulated by miRNAs other the well-described ones. The gene discussed is EZH2; the disease is breast cancer.