CNR1 and Hepatic fibrosis: CB1R also was found to modulate alcohol-induced liver fibrosis.39 A study conducted by Patsenker et al. observed a strong expression of CB1R in the fibrotic septa of patients with alcohol-associated liver cirrhosis, and genetic and pharmacologic inhibition of CB1R attenuated both the hepatic inflammation and the alcoholic liver fibrosis by suppressing HSC activation.39 Although it is well established that CB1R is involved in the development of hepatic steatosis and fibrosis, relatively few studies have examined the role of CB2R in the pathophysiology of ALD.