CNR1 and primary biliary cholangitis: However, CB1R expression is tremendously elevated in pathological conditions, such as alcoholic and nonalcoholic steatosis, primary biliary cirrhosis, and hepatocellular carcinoma.9,19,29 CB2R is rarely expressed in the steady state of the liver, but its expression is elevated in immune cells during the occurrence of hepatic regeneration and diseases such as NAFLD, fibrosis, and hepatocellular carcinoma.29,30 As opposed to the hepatocytes, the cannabinoid signaling in hepatic nonparenchymal cells is relatively less explored.