Serum calcium at a cut-off value 7.65 mg/dL (AUC: 0.376) with sensitivity of 70.0% and NPV of 50.0% (p=0.017), serum albumin at a cut-off value 3.05 g/dL (AUC: 0.250) with sensitivity of 70.0% and PPV of 40.0% (p<0.001), serum phosphate at a cut-off value 4.45 mg/dL (AUC: 0.724) with sensitivity of 90.0% and PPV of 88.9% (p<0.001), and serum urea at a cut-off value 135.88 mg/dL (AUC: 0.665) with specificity of 94.1% and PPV of 72.7% (p=0.001) are predictive of pruritus presence in hemodialysis patients as shown in Table 3 and Figure 2. This evidence concerns the gene ALB and Pruritus.