TAC1 and chronic kidney disease: Pruritus encountered by patients of chronic kidney disease (CKD) is a consequence of multiple factors, primarily metabolic i.e., hypercalcemia, hyperphosphatemia, hypermagnesemia, secondary hyperparathyroidism, aggregation of itch-inducing mediators such as substance P (a neuropeptide), histamine, and complement activation along with interleukins [2-4].