The positive correlation of angiotensin-converting enzyme (ACE) polymorphism with HCM has been well studied [3]. In addition to this, various modifiable risk factors such as hypertension, physical activity, and non-modifiable risk factors such as gender have been studied to explore further the penetrance and severity of phenotypic expression in a population with genetic mutation developed HCM [4]. Along with the genetic, demographic, environmental, and comorbid factors, it is important to note that epigenetics has its place in the pathophysiology of this disease. The gene discussed is ACE; the disease is hypertensive disorder.