Interestingly, in the splenic CD205+G‐MDSC from 4T1 and 4T07 tumor‐bearing mice, the MFI of CXCR4 significantly decreased after 48‐hr fasting; In contrast, CD205+ G‐MDSCs from bone marrow expressed increased levels of CXCR4 (Figure 3e and f). This evidence concerns the gene LY75 and neoplasm.