TP53 and neoplasm: Furthermore, circAMOTL1L overexpression or miR-92a-2-5p depletion decreased the expression of PCNA and Bcl-2 but increased the expression of P53 and Bax in the xenograft tumor, and this situation was further exacerbated by the superposition of the two (Figures 6(g) and 6(h), Supplementary Figures 4a and 4b).