Nevertheless, we do not have a ready explanation for a discrepancy with the findings of other studies that downregulated miR-128 was induced in the failing dog heart and Ang II-induced atrial fibrillation and fibrosis heart [13, 26], and it is possibly due to different experimental subjects, pathology or stress mode, or the stage of disease development. The gene discussed is AGT; the disease is atrial fibrillation.