AKT1 and liver cancer: It was reported that miR-128 regulated the expression of PIK3R1 mRNA and protein through directly targeting PIK3R1 in liver cancer [21], and we thus supposed that the downregulation of miR-128 might inhibit autophagy by affecting Akt/mTORC1 molecules of the canonical autophagy pathway and the downstream of PIK3R1 signaling.