In the PFC and hippocampus of CRS-induced anxiety-model rats, there was an obvious decrease in p-CREB (PFC, p = 0.0081; hippocampus, p = 0.0432) and BDNF (mRNA expression: PFC, p = 0.0003 and hippocampus, p = 0.0234; protein expression: PFC, p = 0.0145 and hippocampus, p = 0.0338) (Figure 8). Here, CREB1 is linked to Anxiety.