Specifically, the Chinese medicine formula JYHH can ameliorate anxiety-like behaviours in rats exposed to CRS by normalising the overactivated HPA axis functions (downregulating the related hormones and upregulating GR), then regulating the 5-HT system (concentrations of 5-HT and 5-HIAA, and the expression of MAO-A and 5-HT1AR), and finally targeting the cAMP-PKA-CREB-BDNF signalling pathway (protein and mRNA expression of related factors). This evidence concerns the gene CREB1 and Anxiety.