In accordance, knockdown of IDH3α, the catalytic subunit of IDH3, decreased the levels of α-KG, NADH, and HIF-1α, diminished the increase in the OCR and mitochondrial oxidative stress, and abolished the decrease in the ECAR and lactate in quiescent cells, consolidating the role of IDH3 in the metabolic switch towards OXPHOS in quiescent melanoma cells. Here, HIF1A is linked to melanoma.