Instructively, we found that quiescent cells from tumour spheroids similarly expressed relatively high levels of c-Myc and the c-Myc-responsive OXPHOS genes, IDH3A, IDH3B, and IDH3G, whereas the levels of c-Myc-responsive cell cycle progression genes, including CDC20, CDC45 and CCNA2 were lower in p27highKi67low quiescent cells compared to cycling cells (Figure S14). The gene discussed is CDC45; the disease is neoplasm.