At day 28 of Ang II infusion in Plod1-/- mice, macroscopic examination of the aortas demonstrated that 55% of mice (11 of 20) showed dissecting AAA formation and 35% of the mice (7 of 20) experienced rupture events when treated with scrambled peptide, whereas TAX2 treatment exhibited strong inhibition of the incidence of the formation of dissecting AAA (4 of 20) (Figure 4A-B). This evidence concerns the gene PLOD1 and triple-A syndrome.