PLOD1 and aneurysm: However, in the present study, the absence of EDS was confirmed by our enrichment analysis based on the Human Phenotype Ontology, indicating that the pathogenesis of aneurysms in LH1-deficient mice, at least in part, from that underlying vascular incidents in EDS patients and that loss of LH1 function may not be the only underlying mechanism responsible for aneurysm formation in EDS patients.