PLOD1 and triple-A syndrome: To further clarify whether LH1 plays a causative role in preventing dissecting AAA formation and to study the potential effect of gene therapy in rescuing the expression of LH1, Plod1-/- mice were intraperitoneally injected with 2×1011 AAV-LH1 or AAV-GFP (as an experimental negative control) in a total volume of 200 μl of supernatant.