Previous RNA expression analyses for BCP-ALL that included MLL-r samples and normal controls 3, 62, 63 reported increased expression of hallmark genes such as FLT3 64 and CSPG4 65 which was confirmed in our study both by transcriptomics and LFQ proteomics (Fig. 7A and 7B). Here, KMT2A is linked to acute lymphoblastic leukemia.