Overall, in the picture of TNF-α/TNFR1-dependent neuronal necroptosis in AD, there appear to be several key successive events, including UVRAG downregulation and autophagic flux impairment and p62 accumulation, which further leads to RIPK1 activation and subsequent neuronal necroptosis (Figure 7H). Here, TNFRSF1A is linked to Alzheimer disease.