PCSK1 and Alzheimer disease: Our data also support the notion that neuronal necroptosis is likely a secondary source of cell death induced by Aβ-mediated neuroinflammation at a later stage in AD, consistent with previous findings that necroptosis inhibitor Nec-1 can block Aβ-induced cell death in APP/PS1 mice, but with limited efficacy at early stages 50.