CD68 and acute kidney injury: Restoration of CD68+ macrophages infiltration by SIVE was accompanied by an increase in staining intensity of growth arrest-specific protein 6 (GAS6), the ligand bridging macrophages to apoptotic cells for efferocytosis 28, 29, which was also occurred upon the combined SIVE and ITEM-2 therapy (P < 0.05 and P < 0.001, Figure 3C-G), suggesting that NETs blockade by itself or in combination with Fn14 mAb increases macrophages infiltration and sustains their efferocytosis during septic AKI.