Immunohistochemical examination of renal sections identified a dramatical reduction in percentage of cells positive for neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of AKI, from CLP mice receiving SIVE plus ITEM-2 combination therapy in contrast to those from mice receiving single therapy (P < 0.05, Figure 2E & F). The gene discussed is LCN2; the disease is acute kidney injury.