In hyperglycemia, it is deduced that high glucose levels induce EndoMT through ERK, Smad2/3, nucleotide-binding oligomerization domain-containing protein 2 (NOD2), ROCK1, and serum response factor in glomerular endothelial cells - this sequence results in increased expression of mesenchymal markers in different types of endothelial cells 143, 144. Here, NOD2 is linked to Hyperglycemia.