PKM and Ureteral obstruction: Consistent with our observation, Ding, H. and co-workers 20 and Yin, X. N. and co-workers 21 observed that PKM2 is upregulated in myofibroblasts of kidney fibrosis unilateral ureteral obstruction (UUO) mouse models and rat kidney NRK-49F cells upon TGFβ stimulation.