In fact, the TF cytoplasmic domain, consisting of 20 amino acids in mice, is not required for TF coagulation activity but mediates TF intracellular signaling pathways via the G-protein-coupled protease-activated receptors (PARs), in particular PAR1 and PAR2, in cancer metastasis, inflammation and angiogenesis 5, 10-12. This evidence concerns the gene TF and cancer.