This decrease was restored by overexpression of LOXL2 in HIF-1α (P = 0.003) and HIF-2α KD (P = 0.009) sEVs (Figure 4D), suggesting that LOXL2 mediates the HIF-1α/HIF-2α-induced invasiveness of HNSCC cells. This evidence concerns the gene EPAS1 and head and neck squamous cell carcinoma.