They further showed that tumor cell-secreted LOXL2 stimulated fibronectin and MMP2 expression by lung fibroblasts in a PI3K-AKT dependent manner, by means of which LOXL2 contributes to lung PMS formation and occurrence of lung metastasis of hepatocellular carcinoma 54. Here, LOXL2 is linked to hepatocellular carcinoma.