Western blotting showed that cells treated with sEVs derived from hypoxic LOXL2 KD HNSCC cells had remarkably decreased expression of vimentin and N-cadherin and increased E-cadherin and ZO-1 levels compared with those treated with wild-type sEVs (Figure 3C). The gene discussed is TJP1; the disease is head and neck squamous cell carcinoma.