Previous research studies found that the treatment effect of ST37 on the ulcerative colitis is better than LI11 in improving the ulcer score, whose mechanism is underlying alleviation of tumor necrosis factor (TNF)-α and increasing the levels of choline acetyltransferase (ChAT) and alpha 7 nicotinic acetylcholine receptor (α7nAChR) [20]. The gene discussed is CHAT; the disease is ulcerative colitis.