COL4A5 and occult macular dystrophy: Among these 10 up-regulated hub genes, most of them such as ALPL, COL4A5 (Sun J. et al., 2021), COL3A1 (Minaříková et al., 2015; Williams et al., 2018), COL11A1 and OMD (Lin et al., 2019, 2021; Ustriyana et al., 2021) are reported to be related to bone mineralization.