The DDR is important because defects in DDR proteins typically cause genome instability that can drive carcinogenesis (Tubbs and Nussenzweig, 2017), and because DDR proteins are important targets to augment cancer therapy (Nickoloff et al., 2017; Desai et al., 2018; Pilie et al., 2019; Nickoloff et al., 2020b; Baillie and Stirling, 2021). Here, DDR1 is linked to cancer.