TLR4 is a known target of miRNA-146a and plays a key role in lipid uptake (Choi et al., 2009); the increase of miRNA-146a protein caused by the rs2910164 polymorphism (Shen et al., 2008; Ramkaran et al., 2014; Xiong et al., 2014) inhibits the expression of TLR4 (Shen et al., 2008), thus reducing lipid uptake and resulting in dyslipidemia. Here, TLR4 is linked to metabolic syndrome.